Rosie O’Donnell is embracing her new look. Per week earlier than her debut in And Simply Like That, O’Donnell shared an Instagram submit displaying off her dramatic weight reduction because of the diabetes remedy Mounjaro.
“i cant consider that is me now #mounjaro #weightloss #bodydismorphia,” O’Donnell captioned an Instagram submit of her performing standup comedy.
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Mounjaro is a model of tirzepatide, a drugs for kind 2 diabetes and weight reduction (much like Ozempic and Wegovy) taken weekly by injection within the thigh, abdomen or arm. Together with O’Donnell, different celebrities together with Elon Musk, Meghan Trainor, Daryl Sabara, and Sophia Umansky have revealed that they’ve used the drug.
O’Donnell’s Instagram submit got here two months after she gave an replace on her expertise with the weight-loss remedy in a TikTok video in March 2025. “I’ve misplaced extra weight. I’m on Mounjaro for my diabetes and one of many unwanted effects is you drop a few pounds,” she mentioned. “Nevertheless it’s additionally as a result of I had a chef for over two years in Los Angeles and I don’t have a chef now. It’s me cooking for Clay and me.”
O’Donnell, who now lies in Eire, shared that she needed to buy groceries in Dublin for brand new garments that “match higher” after her weight reduction. “I’m a kind of individuals who at all times had a weight challenge and now that I’m a dimension giant — as an alternative of an XL or a XXL — I discover it stunning,” she mentioned. “I actually do. I discover it fully stunning.”
O’Donnell revealed that a health care provider put her on Mounjaro and Repatha, one other remedy used to decrease ldl cholesterol, in January 2023. “About two months in the past my physician put me on – not Ozempic – Mounjaro and Rapatha,” she mentioned in response to a fan who requested how she misplaced 10 kilos in between then and Christmas 2022. “One I do each different week and one I do as soon as per week.”
She added that, other than a celebratory champagne toast, she had not drunk “something besides water” since Christmas. “I’m not consuming sugar as a lot as I can,” she mentioned. “My urge for food has decreased considerably. It’s in all probability the meds. And I’m attempting to maneuver extra. So, all these issues mixed, that’s what it’s.”
O’Donnell’s Instagram submit displaying off her weight reduction got here per week earlier than her look in And Simply Like That Season 3, during which she performed Mary, a virgin nun who has intercourse with Cynthia Nixon’s Miranda Hobbes.
“I laughed my ass off. I assumed — I understand how to play this character. I used to be very, very comfortable to be doing all my scenes with Cynthia. It was not performing for me. I don’t need to act in love together with her, as a result of I’ve been in love together with her for a few years,” she informed Selection after the episode aired. “I noticed her in ‘Wit,’ on Broadway, and although I had recognized her for very a few years and was associates together with her in an actual method, after I went backstage, I used to be awestruck and couldn’t discover my phrases.”
She revealed that she was approached for the position by Nixon, whom she described as a “good good friend.” “It was Cynthia. I’m good associates with Cynthia Nixon, and my daughter was truly her assistant on set for the final season of Intercourse and the Metropolis — of And Simply Like That,” she mentioned. “I name it Intercourse and the Metropolis 2, however that’s not it. She put her on there, after which she mentioned, ‘By the best way, Michael informed me that he has a task for you. Are you up for it?’ I mentioned, ‘Are you kidding me? In a minute!’ I didn’t even have to consider it.”
She continued, “I’ve recognized Michael Patrick King for in all probability over 30 years. Once I was a younger comic, he was in a comedy duo referred to as King and Mindy — Lisa Mindy and Michael King. I used to hang around with them at Catch a Rising Star and on the Improv. It’s been fairly superb to see the those that started collectively doing so nicely.”
And Simply Like That streams on Max.